Genetically Modified Mesenchymal Stem Cells Induce Mechanically Stable Posterior Spine Fusion
نویسندگان
چکیده
منابع مشابه
Genetically modified mesenchymal stem cells induce mechanically stable posterior spine fusion.
Most spine fusion procedures involve the use of prosthetic fixation devices combined with autologous bone grafts rather than biological treatment. We had shown that spine fusion could be achieved by injection of bone morphogenetic protein-2 (BMP-2)-expressing mesenchymal stem cells (MSCs) into the paraspinal muscle. In this study, we hypothesized that posterior spinal fusion achieved using gene...
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Spine disorders and intervertebral disc degeneration are considered the main causes for the clinical condition commonly known as back pain. Spinal fusion by implanting autologous bone to produce bony bridging between the two vertebrae flanking the degenerated-intervertebral disc is currently the most efficient treatment for relieving the symptoms of back pain. However, donor-site morbidity, com...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2010
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2009.0786